Chinese anatase titanium dioxide has become a popular topic in the field of materials science due to its unique properties and wide range of applications. Anatase titanium dioxide is a type of titanium dioxide with the chemical formula TiO2, and is known for its high refractive index, excellent UV resistance, and good photocatalytic activity.
The EU expert panel did not identify an immediate health concern linked to TiO2 when used as a food additive. However, due mainly to uncertainties concerning the safety of TiO2 nanoparticles, the panel concluded that TiO2 as a food additive (E171) could no longer be considered safe.
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A study published in the Journal of Agricultural and Food Chemistry in 2019 sought to examine the effects of titanium dioxide on intestinal inflammation. Researchers did this by feeding rats titanium dioxide nanoparticles and found that, after the course of two to three months, the animals had lower body weights and induced intestinal inflammation. The researchers also found the nanoparticles altered gut microbiota composition and aggravated chronic colitis. The rats also experienced reduced populations of CD4+T cells (which are cells that help organize immune responses by prompting other immune cells to fight infection), regulatory T cells, and white blood cells in mesenteric lymph nodes. The researchers wrote: “Dietary TiO2 nanoparticles could interfere with the balance of the immune system and dynamic of gut microbiome, which may result in low-grade intestinal inflammation and aggravated immunological response to external stimulus, thus introducing potential health risk.”